بررسی اثر عصاره هیدروالکلی گیاه خوشاریزه (Echinophora platyloba L.) بر غلظت سرمی تستوسترون و گنادوتروپین‌ها در موش صحرایی نر القا شده با تتراکلرید کربن

Background and Objective: Carbon tetrachloride is one of the chemical toxins widely used in hygiene industries. The aim of this study was to investigate the effects of Echinophora platyloba extract (EPE) on serum levels of testosterone and gonadotropins in male rats induced with carbon tetrachloride. Materials and Methods: In this experimental study 49  male Wistar  rats (220-250 g) were randomly divided into seven groups (n=7): Control group (2 ml/kg  normal saline, daily for 4 days, ip), toxicant group (2 ml/kg CCl4+olive oil.1:1, single dose ,ip), sham group (2 ml/kg  olive oil, single dose, ip), positive control group (400 mg/kg EPE daily for 4 days, ip), toxicant-treated groups 1, 2 and 3 (CCl4+ olive oil.1:1, single dose and 200 and 400 and 800 mg/kg of EPE, respectively, daily for 4 days, ip). At the end of the treatments, serum testosterone and FSH & LH hormones were measured. Results: CCL4 resulted in significantly decreased testosterone and increased FSH & LH serum levels in the toxicant group compared with the control group (P<0.001). EPE treatment with 400 and 800 mg/kg resulted in a significant increase in testosterone and decrease in FSH & LH serum levels compared with the toxicant group (P<0.001).    Conclusion: Hydro-ethanolic E. platyloba extract increased serum levels of testosterone and decreased FSH and LH serum levels in male rats induced with CCL4.